Abstract
INTER RELATIONSHIP BETWEEN BLOOD LEAD CONCENTRATION AND OXIDATIVE CARDIAC RISK PARAMETERS IN ADULTS: EFFECT OF ASCORBIC ACID

Prof. Ipsita Mazumdar* and Prof. Krishnajyoti Goswami

ABSTRACT

It is well known that chronic lead exposure leads to various health hazards. Along with lead, it has also been seen that homocysteine, pyridoxine, cobalamine and folate are linked to cardiovascular complications, oxidative stress and a lot of other lifestyle disorders. In the present study, the relationship between these various parameters and chronic lead exposure was evaluated in lead smelting industry and jewelry industry workers, with an more than 10 years of working experience. Ascorbic acid, a known antioxidant, was administered in controlled doses over a specific period of time to study its effects on the said parameters. Method: Samples were analysed for homocysteine using Fluoroscence Polarisation Immunoassay, Vitamin B12 and Folate using ECLIA method, and malondialdehyde and RBC Superoxide dismutase were assayed with kits suppled by Randox Lanoratories. Blood Lead levels were measured by atomic absorption spectrophotometry. Results: Results showed a significant decrease in all parameters except malondialdehyde in chronic lead exposed workers. On administration of a controlled dose of ascorbic acid, over a specified period of time, most parameters were seen to be statistically significantly altered towards a healthier side. Conclusion: A significant positive association was detected between lead exposure and oxidative stress with cardiovascular effects, which was seen to be improving upon administration of Ascorbic acid over a specific period.

Keywords: Lead, Homocysteine, SOD, Vitamin B12, Ascorbic Acid.


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