Abstract
DEVELOPMENT AND VALIDATION OF ABSORPTION RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE IN COMBINE DOSAGE FORM

Shubham Murlidhar Chaudhari*, Sachin Shrikrushna Rane, Prof. (Dr.) Rajesh Yadav Chaudhari and
Prof. (Dr.) Vijay Raghunath Patil

ABSTRACT

A simple, robust, precise, UV spectroscopic method has been developed for the simultaneous estimation of Azilsartan medoxomil and Chlorthalidone in bulk and tablet dosage forms. In this paper the estimation of those drugs was carried out by absorbance ratio method. This method is based on measurement of absorption at 254nm and 241nm i.e, λmax of Azilsartan medoxomil and Chlorthalidone respectively. The linearity observed for Azilsartan medoxomil is in the range of 24-120 μg/ml and for Chlorthalidone is in the range of 10-50 μg/ml. The accuracy of method was found to be within the range of 99.77%-99.69% for both Azilsartan medoxomil and Chlorthalidone respectively. The developed methods were validated with respect to linearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceutical formulations with no interference from any excipients and diluents. The results were validated as per ICH guidelines.

Keywords: Azilsartan medoxomil, Chlorthalidone, Absorbance Ratio Method, Validation.


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