Abstract
SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIENO-1,2,3- TRIAZINES

Saravanan Janardhanan* and Manju Bharghavi

ABSTRACT

The main aim of this work was to synthesis a thieno-1,2,3- triazines by using Gewald reaction and its analogues were synthesized by diazotization; 3-N-p-tolyl-5,6-dimethyl thieno[2,3-d][1,2,3]-triazin-4-(3H)-one, 3-N-methyl-5,6-trimethylene thieno-[2,3-d][1,2,3]-triazin-4-(3H)-one, 3-N-(4-chloro phenyl)–5,6-trimethylene thieno[2,3-d][1,2,3]-triazin-4-(3H)-one and 3-N-methyl–5,6-tetramethylene thieno[2,3-d][1,2,3]-triazin-4-(3H)-one. The synthesized thieno-1,2,3- triazines derivatives subjected to in vitro anticancer activity screening by using MTT assay in Ht29 colon cancer cell lines and Doxorubicin as standard. The prepared analogues were characterized by FT-IR, 1H-NMR and mass spectra. The result reveals that most of the synthesized compounds showed anticancer properties.

Keywords: Gewald reaction, Diazotization, Anticancer activity, Doxorubicin.


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