Abstract
PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF TURMESAC® ON PARACETAMOL-INDUCED LIVER TOXICITY IN RATS

C. T. Sadashiva*, H.M. Firoz Hussain and S. Nanjundaiah

ABSTRACT

The present study were carried out to assess hepatoprotective potential for Turmesac® (formulated by using turmeric rhizome extract) against paracetamol (PCM) induced hepatotoxicity in rats. Oral administration of Turmesac® in two doses 250mg/kg and 500mg/kg body weight were subjected for the evaluation of hepatoprotective potential against PCM (2g/kg) induced liver injury. Silymarin (50mg/kg) was used as a standard drug. The biochemical parameters like serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), glutathione (GSH), super oxide dismutase (SOD), total bilirubin (TBR), total protein (TP) and catalase (CAT) were assayed in liver homogenates for all studied groups. In addition histopathological study was also carried out. The results revealed significant decrease in SGPT, SGOT and TBR and increase in GSH, TP, SOD and CAT levels when compared with toxic control. These data indicate that Turmesac® is a natural antioxidant hepatoprotective agent against hepatotoxicity induced by paracetamol model. Thus, Turmesac® may have a therapeutic value of drug-induced hepatotoxicity as well as in paracetamol therapy.

Keywords: Turmesac®, Hepatoprotective activity, Paracetamol, Silymarin.


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