European Journal of Biomedical and Pharmaceutical Sciences

THE MEDICINAL EFFECT OF GARCINIA KOLA TINCTURE ON THE COGNITO-MOTOR

*Olorunfemi Oluwadare J., Asara Azibalua A. and Baulch Ebibodere K.

ABSTRACT

The medicinal effect of Garcinia kola tincture on the cognito-motor balance and gait pattern was investigated in wistar rats. Twenty Wistar rats, weighing 100-150 g, were used for this study. The rats were randomly assigned into four groups with five rats each. Group 1 rats served as control and were given no treatment. Group 2 rats were administered low dose of Garcinia kola tincture (0.5ml/100kg), orally. Group 3 rats were also administered with high dose of Garcinia kola tincture orally (1ml/100g) orally. Group 4 rats were given diclofenac drug (0.01mg/100g), intraperitoneally. Neuro - behavioural test for memory, learning and motor co-ordination as well as gait assessment were carried out on all the groups using Barnes- maze, passive-avoidance, navigational tasks and rotarod test. The outcome of this study was statistically analyzed using ANOVA. The high and low dosage group of Garcinia kola tincture showed improved cognitive ability (learning &memory) compared to the control group during Barnes-maze and passive-avoidance tests but a decline in navigational task. There was no significant effect of Garcinia kola tincture on motor coordination in wistar rats observed in the study. In conclusion, the results of the present study demonstrated that Garcinia kola tincture increases cognition in wistar rats but has no effects on the motor activities and locomotion in the rats.

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