Abstract
ULTRA-SENSITIVE ESTIMATION OF VARDENAFIL. HCL IN PHARMACEUTICAL PREPARATIONS AND ENVIRONMENTAL WASTE WATER SAMPLES

Nief Rahman Ahmed*, Amenah Ibrahim Ahmed and Hiba Younis Qasim

ABSTRACT

A simple, accurate, precise, rapid, economical and high sensitive UV spectrophotometric method has been developed for the estimation of vardenafil hydrochloride in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 214 nm in distilled water. Beer's law was obeyed in the range of 0.1-2μg/ ml, with molar absorptivity of 4.745×105 L.mol-1. cm-1, relative standard deviation of the method was less than 1.9%, and accuracy (average recovery %) was 100 ± 1.03. No interference was observed from common excipients and additives often accompany with vardenafil hydrochloride in pharmaceutical preparations. The method was successfully applied to the estimation of vardenafil hydrochloride in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of vardenafil hydrochloride in true samples.

Keywords: Vardenafil. HCL, Pharmaceutical Preparations, Environmental Samples, Ultraviolet.


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