Abstract
ROLE OF DOPAMINE D2 RECEPTOR IN CHOLINERGIC INTERNEURON IN RESPONSE TO COCAINE

Elmira Mofid MD*, Sukhrajwinder Sekhon MD, Casem Ballouk MD, Olha Huzo MD

ABSTRACT

Dopamine (DA) is the predominant catecholamine neurotransmitter in the human center nervous system, where it controls a variety of functions including cognition, emotion, locomotion activity, hunger and endocrine system regulation. The effects of the DA are brought about when DA interacts with the membrane bound dopamine receptors that belong to the G-protein coupled receptor family. There are five different types of DA receptors which are subdivided into two subfamilies; first, the D1-like that includes D1R, D5R and second, the D2-like that includes D2R, D3R and D4R. Dopamine is synthesized by the neurons of the substantial nigra and ventral tegmental area (VTA), and by hypothalamic neurons of the arcuate and periventricular nuclei (8). Projections originating from brain areas that synthesize this neurotransmitter give rise to four axonal pathways which are (i) nigro-striatal; (ii) mesolimbic; (iii) mesocortical; and (iv) tuberoinfundibular (7). The mesolimbic pathway originates from the midbrain VTA and innervates the ventral straitum, the olfactory tubercle (OT) and parts of the limbic system (7). This pathway has been implicated in the control of the reward mechanisms and in the psychomotor effects generated by drugs of abuse, including cocaine.

Keywords: .


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT