Abstract
SUB-LETHAL TOXICITY OF LAMBDA-CYHALOTHRIN ON REPRODUCTIVE BIOMARKERS OF FEMALE WISTAR RATS

*Iheanacho J.U.I., Onyeka P.I.K., Okafor A. I., Udujih, H. I. and Okoroigbo F. I.

ABSTRACT

A study on Sub-lethal Toxicity of Lambda-Cyhalothrin on reproductive biomarkers of female Wistar rats were carried out using approved protocols by institutional animal ethics committee and guide lines of National Research Council for care and maintenance of animals. Three concentrations 0.2%, 0.4% and 0.8% of sub-lethal solutions were prepared and administered to three treatment groups of female Wistar rats through feed. At the end of treatment period, blood samples were collected for reproductive hormonal analysis. The results showed that Wistar rats in the treatment groups had a significant dose dependent decrease in serum estrogen, FSH and LH levels while progesterone had a non-significant dose dependent decrease across treated rats. It is therefore necessary to create public awareness on the possible toxic effects of Lambda-Cyhalothrin. Also, further studies should be conducted on its exposure and risks to humans.

Keywords: Lambda-Cyhalothrin, reproductive biomarkers, female Wistar rats.


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