European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF ANTIBIOTIC SENSITIVITY OF STAPHYLOCOCCUS AUREUS AS A CAUSE OF URINARY TRACT INFECTION IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

*Swati S. Kale

ABSTRACT

Background: Staphylococcus aureus is a relatively uncommon cause of urinary tract infection in the general population. However, recent epidemiologic studies indicate that S. aureus is an emerging cause of UTI in special patient populations, such as pregnant women and those with complicated UTI. Of particular concern, complicated S. aureus UTIs are frequently associated with the development of severe sequelae, leading to increased rates of morbidity and mortality. Material and methods: Staphylococcus aureus isolates obtained from various urine samples were studied from January 2015 to October 2017 in the Microbiology Diagnostic Laboratory for their antibiotic sensitivity and co-morbidities. Results: A total of 2590 urine culture positive samples were received in Diagnostic Microbiology Laboratory during the study period. Out of these S. aureus was found in 69 samples. (2.66%). Out of these 69 urine samples, 31(56.52%) were from Catherized and 38(50.72%) from non-Catheterized patients. Out of 69 samples 57 (82.60%) patients had some or the other co-morbidities such as Diabetes, Hypertension, post menopausal females, pregnant females etc. Antibiotic sensitivity testing was done for all S.aureus isolates. Highest antibiotic sensitivity was seen towards Vancomycin and Pristinamycin(100%). Least sensitivity was seen towards Penicillin G in both MRSA and MSSA isolates. Conclusion: Urinary tract infections caused by multi drug resistant S.aureus is an emerging problem in hospitals. infection control practices play a vital role in controlling these life threatening infections. Vancomycin, cotrimoxazole and nitrofurantoin are good options for empirical treatment of MRSA UTIs. Pristinamycin is also a good option for treating UTI caused by MRSA.

Keywords: Staphylococcus aureus, Urinary tract infections, Antibiotic sensitivity.