Abstract
DIAGNOSIS OF TUBERCULOSIS AND DRUG RESISTANT TUBERCULOSIS IN PLHA (REGISTERED AT ART CENTRE TIRUNELVELI) USING CB-NAAT

Dr. Marchwin K. S., *Dr. J. Bharath and Dr. A. Ravi

ABSTRACT

Background: Tuberculosis is the commonest opportunistic infection seen in Patients infected with HIV and Pulmonary TB is the commonest form of the disease. The aim of this study was to assess the role of CBNAAT in diagnosing tuberculosis and drug resistance in TB in HIV infected persons and its comparison with routine sputum AFB microscopy. Methods: Cross sectional descriptive study. 200 HIV infected patients were recruited for the study and the prevalence of pulmonary tuberculosis was assessed both with sputum AFB microscopy and sputum CBNAAT. Extrapulmonary tuberculosis was identified with relevant tests. The epidemiological details of the patients were obtained and tabulated to derive the conclusions. Results: The prevalence of Tuberculosis in HIV infected individuals as per this study was found to be 15%.The overall prevalence of Pulmonary TB in the given population is 13% and extra pulmonary is 2%. This study also suggests that meals with HIV have a higher incidence of Tuberculosis. The study also revealed that sputum CBNAAT is more efficacious than sputum microscopy for detection of FB and the prevalence of rifampicin resistance in TB among HIV infected individuals was 10%. Conclusion: Sputum CBNAAT is a valuable test for diagnosing colossus both in HIV infected and non infected people and it has an additional advantage of identifying rifampicin resistance thereby making it and effective screening tool for MDR TB.

Keywords: Tuberculosis, HIV, PLHA, CB-NAAT.


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