European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND STUDY OF ARYL SUBSTITUTED 1,3-THIAZINE AND ITS NANOPARTICLES WITH SPECIAL REFERENCE TO PLANT PATHOGENS OF SOME VEGETABLE CROPS

Chhaya D. Badnakhe* and P. R. Rajput

ABSTRACT

The synthesis, spectral analysis and biological activities of 4-phenyl-2-hydroxy-chlorosubstituted-2-imino-1,3 thiazines have been carried out. In this case 4-(2'-hydroxy-3',5'-dichlorophenyl)-6-(4"-nitrophenyl)-2- iminophenyl-3,6-dihydro-1,3-thiazine (B) has been screened. The compound (B) was synthesized from 2'-hydroxy-3,5-dichlorophenyl-4-(4”-nitrophenyl) chalcone (a) by the action of phenylthiourea. The compound (a) was synthesized from 2’-hydroxy-3’,5’-dichloroacetophenone by the action of p-nitrobenzaldehyde in ethanol and 40% NaOH. The nanoparticles of the compounds (B) has been prepared by using ultrasonic technique. The titled compound and its nanoparticles were assayed for antipathogenic impact against some common crop pathogens viz - Aspergillus niger, Pseudomonas lachrymans, Fusarium oxysporum and Fusarium solani.

Keywords: Chalcone, thiazine, phenylthiourea, antipathogenic activities.