European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF THE ASSOCIATION BETWEEN ANTI-MÜLLERIAN HORMONE AND OTHER REPRODUCTIVE PARAMETERS IN HEALTHY AND POLYCYSTIC OVARY SYNDROME WOMEN

*Dr. Fidaa Najim Abdullah and Dr. Bushra Farhan Awadh

ABSTRACT

This prospective clinical study was performed to correlate Anti-Müllerian hormone (AMH) levels with years since menarche as well as to investigate the AMH association with ovarian morphology and levels of androgens in healthy normo- ovulatory women and in women with polycystic ovary syndrome (PCOS) in Al-Falluja teaching hospital for gynecology and pediatrics at Falluja-Anbar /Iraq. In our study, (30) healthy normo-ovulatory women and (40) women with PCOS were recruited on the basis of the classic PCOS criteria (Rotterdam consensus meeting definition of PCOS (ESHRE/ASRM, 2004). Fasting blood was obtained from all women in the early follicular phase (days 5-6) after spontaneous or induced menses (in PCOS), and transvaginal ultrasound examination was performed. The values for follicular stimulating hormone (FSH), testosterone (T), AMH as well as the years since menarche and ovarian volume were assessed. Results showed that AMH had a statistically significant positive correlation with the ovarian volume (r =0.625, r =0.581 P<0.01) and negative correlation with years since menarche (r =-0.745, r =-0.801 (P<0.01) in both study groups. In women with PCOS, AMH and years since menarche had a significant correlation with testosterone (r =0.450, r = -0.595, P<0.01). It can be concluded from this study the relation between AMH and years since menarche as well as the AMH differences in relation with certain clinical or endocrine characteristics between normal and PCOS women were underlined.

Keywords: Anti-Müllerian hormone, Menarche, Ovarian volume, Testosterone, PCOS.