Abstract
EVALUATION OF PACKAGING MATERIAL INTERACTION IN PHARMACEUTICAL PREPRATION

Dinesh Kamdi*, Dr. K. B. Gabhane and C. A. Gulhane

ABSTRACT

Plastic materials are widely used in medical items, such as solution containers, transfusion sets, transfer tubing and devices. While an important performance characteristic of plastics used in medical application is chemical inertness, interactions between a plastic material and a contacted pharmaceutical Products are well documented. In the case of leaching, both the identity of the leached substances and their accumulation levels may impact the ultimate utility of the product. In this article Summarizes the packaging material interaction with; product material affects the product quality. A review is provided related to the accumulation of organic and inorganic leachable substances from DEHP plasticized PVC, polyolefin and various other related pharmaceutical plastic packaging materials.

Keywords: Plastic Material, Extractable, leachable, PVC, DEHP.


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