Abstract
FORMULATION APPROACHES AND CHARACTERIZATION OF IMMEDIATE RELEASE DOSAGE FORM

Akash Umesh Mahajan and Ashish Prakash Gorle*

ABSTRACT

Oral route of administration is most convenient route of drug administration about 85% of available dosage form is in market are developed by considering oral route. The development of pharmaceutical dosage form like tablet requires considering the parameters like the bioavailability of API. The conventional tablets takes time to disintegrate, to overcome this development of immediate release tablet is done. The disintegration time of immediate release dosage form is lowered by using the superdisintegrants like Sodium starch glycolate, Crospovidone (Polyplasdone) and Carboxymethylcellulose (Croscarmellose). The superdisintegrants lead to rapid disintegration of tablet in stomach after administration and makes drug offered for dissolution. The fast disintegration is may be due to quick uptake of water from the medium and provides swelling and burst mechanism. This article provide the detailed information of significance of superdisintegrants in the immediate release of tablet and the mechanism of disintegration along with various conventional techniques and novel granulation technology used to prepare immediate release tablet.

Keywords: IR tablets, Characterization, Granulation Techniques, Methodology.


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