A REVIEW ON TRANSUNGUAL DRUG DELIVERY SYSTEM AS NOVEL DELIVERY
Meraj Siddiqui Israfil Siddiqui* and S. D. Pande
ABSTRACT
The body normally hosts a variety of microorganisms, including bacteria and fungi. Some of these are useful to the body and others may cause infections.Nail plate is main route for penetration of drug. Nail plate is main route for penetration of drug. The nail grows at a rate of approximately 1.8-4.5 mm per month or 0.1 mm per day; thus, the average nail can regrow completely in 6-9 months. The hardness and the impermeability of the nail make it an unpromising route for the drug delivery. Topical therapy is most preferable option, due to its non-invasiveness, localised action, elimination of systemic adverse effects and drug interactions, increased patient compliance and possibly reduced cost of treatment. The nail unit is made up of nail plate; nail matrix, nail bed, hyponychium and also the proximal and lateral nail folds as shown. Onchomycosis generally affects 10-40% of populations. Topical nail preparations like lacquers, varnishes, enamels etc. are generally used to enhance beauty of nails, imparting color and luster to nail. Iontophores involves delivery of a compound across a membrane using an electrical field (electromotive force). Keratolytic agents (papain, urea, and salicylic acid) may be used to improve penetration of anti fungal drugs.
Keywords: Transungual Drug Delivery, Human Nail, Onychomycosis, Medicated Nail Lacquer.
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