Sai Theja Guduru*, A. Santhi Sri, S. Kalma, Y. Jessie Grace, K. Yalla Reddy, P. V. Madhav Reddy


A drug- drug interaction is a pharmacological or clinical response to the administration of two or more drugs which is different from the response triggered by the individual use of these agents. The risk of drug-drug interactions with increases exponentially with number of drugs prescribed and is estimated of approximately 6% when 2 to 4 drugs are used, 50% when 5 drugs and nearly 100% when 8 drugs are prescribed. Drug interactions can occur both in-vivo and in-vitro. Drug interactions outside the body can occur when different drugs are mixed in an intravenous infusion. Poly therapy increases the complexity of the therapeutic management and there by the risk of clinically important drug -drug interactions which can both induce the development of adverse drug reaction or reduce the clinical efficacy. In general, a drug is a chemical substance meant for rectifying the altered physiological condition in the body. But currently drugs are becoming an important entity in the daily life of many individuals as the use of poly medication is increasing irrespective of rationality. Whatever it may be the cause for poly-medication, each and every drug encounters when they are concomitantly administered. Our study on drug-drug interactions helps in assessing the prevalence of potential drug-drug interactions and reducing their risk and adverse consequences also helps in focusing on the rational prescription of drugs. By minimizing the harmful drug-drug interactions as they are more in number when compare to beneficial interactions. Our study also aids in minimizing the medication related problems in patients at risk and improving the role of clinical pharmacist in pharmaceutical care.

Keywords: drug -drug interactions, poly medication, poly pharmacy, drug-related problems.

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