European Journal of Biomedical and Pharmaceutical Sciences

ANTIBACTERIAL AND ANTIFUNGAL STUDY ON NOVEL Ag(I)-15C5 COMPLEXES

Seema Chitlangia and Rajeev Ranjan*

ABSTRACT

Crown ether is a general name given to macrocyclic polyethers containing ethylene bridges separating electronegative oxygen atoms. They typically contain central electron rich hydrophilic cavity with diameter varying from 1.2-6.0 Å. Crown ethers have been used for the various studies pertaining to extraction equilibrium constant, stability constant and for determination of some of the alkali and alkaline earth elements and other elements from p, d and f-block elements. Crown ethers have a significant coordination power towards silver ion. The present paper describes synthesis, characterization and antimicrobial study of novel Ag(I) complexes synthesized by 15-crown-5 ether. The organic salts used for complexation were salts of nitrophenols. Products were isolated from silver salts of all the three nitrophenols, 2-nitrophenol(ONPH), 2,4-dinitrophenol(DNPH) and 2,4,6-trinitrophenol(TNPH), having general formula of [Ag.L](Pic-), where L = 15C5 and Pic- = Picrate anion. Elemental analysis, molar conductivity, UV-Vis, IR, and 1H-NMR spectral analysis were performed for establishment of the structure of synthesized complexes. Antibacterial activities of the synthesized complexes were determined by using Kirby Bauer disc diffusion method. Antibacterial and antifungal activity of the prepared complexes were determined and recorded by zone inhibition method.

Keywords: 15C5, ONPH, DNPH, TNPH.