Abstract
SYNTHESIS AND ANTIBACTERIAL ASSAY OF NANOPARTICLES OF SUBSTITUTED 1,3-THIAZINES

Chhaya D. Badnakhe*, P. R. Rajput

ABSTRACT

The synthesis, spectral analysis and biological activities of 4-phenyl-2-hydroxy-chlorosubstituted-2-imino-1,3 thiazines have been carried out. In this case 4-(2'-hydroxy-3',5'-dichlorophenyl)-6-(hexyl)-2-imino-3,6-dihydro-1,3- thiazine (G) has been screened. The compound G was synthesized from 2'-hydroxy-3’,5’-dichlorophenyl-4-(hexyl) chalcone (a”) by the action of thiourea. The compound (a”) was synthesized from 2’-hydroxy-3’,5’-dichloroacetophenone by the action of heptanaldehyde in ethanol and 40% NaOH. The nanoparticles of the compounds G has been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activities against some Gram positive Staphylococcus aureus and Streptococcus sp. and Gram negative Pseudomonas sp. and Solmonella typhi pathogens. All the newly synthesized compounds were found to be active against test pathogens.

Keywords: Chalcone, thiazine, thiourea, antibacterial assay.


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