Abstract
A COMPARATIVE STUDY ON VALIDATION OF RANOLAZINE AND LACOSAMIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC METHOD

Masma Shaik* and Y. Sunandamma

ABSTRACT

A reversed phase high performance liquid chromatographic (RP-HPLC) method was developed for the determination of ranolazine and lacosamide in pharmaceutical formulations. A comparative study was made on the results obtained to evaluate the strong and weak aspects of the reported method. Hypersil BDS-C8 column with sodium acetate-acetonitrile (50:50) mobile phase was employed for the determination of ranolazine in the range 0 to 150 μg mL-1. Completely resolved peaks were observed at 4.74 min and at 5.00 min retention times for standard and samples of ranolazine respectively. The precision (RSD = 0.2%) and accuracy (recovery = 100.4 – 100.5%) of the proposed method were found to be good. Lacosamide in pharmaceutical formulations was determined using Inert sustain HP C18 as stationary phase, a mixture of potassium dihydrogen phosphate (pH 2.0) and acetonitrile (90 : 10 v/v) as mobile phase A, ,mixture of acetonitrile and water (60 : 40 v/v) as mobile phase B. The method with high precision (RSD 0.04 %) and good accuracy (recovery 98.8 – 101.4 %) is useful for the determination of lacosamide in the range 0 to 150 μg mL-1. Both the methods were found to be highly robust.

Keywords: .


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: JULY ISSUE PUBLISHED

    JULY 2021 Issue has been successfully launched on 1 July 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT