Abstract
HYPOGLYCEMIC AND TISSUE-PROTECTIVE EVALUATION OF FICUS KRISHNAE IN ALLOXAN-INDUCED DIABETIC RATS

Amarvani P. Kanjikar and Ramesh L. Londonkar*

ABSTRACT

Diabetes is the most common endocrine disorder associated with carbohydrate metabolism and is a major cause of disability and hospitalization. Ficus krishnae belongs to the family Moraceae has been used in ancient folklore medicine the parts of this plant such as Stem bark and leaves are used to treat diabetes. Hence the present study is aimed to investigate the anti-diabetic activity of methanol extract of Ficus krishnae Linn in alloxan induced diabetes albino rats. Alloxan was administered as a single dose (120 mg/kg, b.wt) to the normal rats to induce diabetes. Oral administration of methanol extracts from stem bark of Ficus krishnae at the dose of 200 & 400 mg/kg body weight/day for 14 days was treated to alloxan-induced diabetic rats. The fasting blood sugar levels, body weight, serum biochemical analysis and histopathology study were conducted in alloxan-induced diabetic rats. On the basis of our findings, it is confirmed that the F.k stem bark could be used as potential antidiabetic agent for better management of diabetes mellitus.

Keywords: Ficus krishnae, Diabetes mellitus, Acute toxicity, Albino rats, Soxhlet extraction.


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