Abstract
ROLE OF MITOCHONDRIA IN AGING RETARDATION IN RATS IN ONTOGENESIS AT FEEDING BY A LOW-CALORIE DIET

Mirzaolimov Mirzahid Mirzavaliyevich., Abdullayev Gafurdzan Rakhimdzanovich,
*Akhmerov Rashid Nasypovich and Soliyev Elmurad

ABSTRACT

Feeding of growing rats by a calorie-restricted diet (CRD) leads to a pronounced threefold backwardness in body mass and more than twofold backwardness in the mass of the liver of animals from control values. Also, gas-oxygen metabolism is reduced when using CRD. It is shown that respiratory suppression of V3 and V4 in liver mitochondria is approximately 10-20% in succinate, and there is a NADH uncoupled oxidation decrease in mitochondria under these conditions to 40%, which can lead to the economical use of the organism’s energy resources. Peroxidation, in contrast, in liver mitochondria is maintained at approximately 20-30% higher level during the weight of the experimental period with CRD compared to the control. The role of the identified alterations in prolonging the life of animals is discussed.

Keywords: calorie restricted diet-CRD, mitochondria, ROS - reactive oxygen species, uncoupled respiration, ageing, prolonging the life.


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