Abstract
A COMPARATIVE EVALUATION OF THE HAEMATOPOIETIC POTENTIALS OF ETHANOLIC EXTRACTS OF TALINUM TRIANGULARE, TELFAIRIA OCCIDENTALIS AND AMARANTHUS HYBRIDUS ON 2,4-DINITROPHENYLHYDRAZINE (DNPH) INDUCED ANAEMIC WISTAR RATS

Chinko BC.*, Egbejimi AM, Hart VO., Okpalaji CB., Onyebuenyi MO., Okuremi HO. and Ododo A.

ABSTRACT

Anaemia is global public health problem with prevalence higher among low-income countries. The prohibitive cost of treatment has continued to fuel interest in the screening of medicinal plants for their anti-anemic potentials. This study is aimed at comparing the efficacies of Talinum triangulare, Telfairia occidentalis and Amaranthus hybridus on 2,4-Dinitrophenylhydrazine (DNPH) induced anaemic Wistar rats. The study was conducted using 45 male adult Wistar rats. Anaemia was induced using a 10 days oral administration of DNPH. The animals were treated using 30 and 60mg/kg ethanolic leaf extracts and a standard anti-anaemic drug. Haematological parameters were analyzed using standard automated methods. Results from this study indicate that treatment with ethanolic leaf extracts of T. Triangulare, T. Occidentalis and A. Hybridus all caused significant increase in the mean values of PCV, HGB, RBC, MCH, MCHC and MCV compared with the untreated anaemic rats(P<0.05). A. Hybridus caused the highest percentage increase in PCV(59.7%), HGB(48.4%), MCH(18.7%), MCV(32.6%), followed by T. Occidentalis and T. Triangulare in a decreasing order. Also, T. Triangulare and A. Hybridus caused a significant reduction in the values of WBC compared to the untreated animals (p<0.05) while the ethanolic extract of T. Occidentalis caused a significant increase in WBC compared to the untreated animals (p<0.05). Only etA. Hybridus significantly raised platelet count compared with the untreated anaemic animals (p<0.05). The present study has further validated the anti-anaemic potentials of the individual extracts of T. Triangulare, T. Occidentalis and A. Hybridus while showing their various degrees of efficacy.

Keywords: Anaemia, Haematology, Talinum triangulare, Telfairia occidentalis, Amaranthus hybridus, 2,4-Dinitrophenylhydrazine.


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