TOXICOLOGICAL IMPACTS OF MALATHION WITH PEG-600 AS FORMULATING ADJUVANT
Sayed M Rawi, Mansour A Al-Hazmi, Seif El-Nasr F and Ayed S Al- Logmani
ABSTRACT
The effects of the organophosphorus insecticide, malathion and polyethylene glycol-600 as adjuvant,
were evaluated on the quail Coturnix coturnix. These compounds were tested separately and as a
mixture because they can be applied together for different applications and therefore have the potential acts as
a binary mixture. The acute mortality (LD50) after 96 hours were estimated to be 583 and 395 mg/kg. for
malathion individually and In combination with the studied adjuvant, respectively. At the dose level ¼ LD50
malathion alone or in a mixture with PEG was found to induce severe histopathological changes in liver, brain
and kidney tissues and has a potent effect on the levels of plasma total protein, albumin, total lipids, and
ALP, GOT, GPT and AChE activities. However, exposure to the mixture caused more severe histological
changes and significantly induced greater effects in the studied biochemical than either compound
alone. These results indicate that agricultural adjuvants and pesticides may cause more damage as a mixture
than either product alone. Therefore, future evaluations of pesticide effects should consider the effects of
adjuvants as a mixture with pesticides when these products are recommended to be applied together for pest
control.
Keywords: Malathion - Polyethylene glycol – Biochemistry – Histopathology.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
