Abstract
BERBERINE AND ITS PHARMACOLOGY POTENTIAL: A REVIEW

Prajwala B., Raghu N., Gopenath TS, Shanmukhappa B. Kaginelli, Karthikeyan M., Ashok G., Ranjith MS., Srinivasan V. and Kanthesh M. Basalingappa*

ABSTRACT

Berberine is a naturally occurring yellow plant extract with a long history of medicinal uses in Ayurvedic and Chinese medicines. It is an alkaloid present in root, stem, bark, leaves and rhizomes of Berberis vulgaris, Tinospora cordifolia and many other plants. Berberine activates the enzyme called AMPK, which regulates biological activities that normalize lipid, glucose and energy imbalances. Studies have shown that berberine has various pharmacological functions such as anti-diabetic, anti-bacterial, anti-viral, anti-cancer, anti-inflammatory effects. Berberine is possibly safe to most adults for short term use and it is unsafe to newborn, infants, pregnant and nursing women and diabetic patients. The present review summarizes the pharmacology and medicinal uses of berberine.

Keywords: Berberine, AMPK, berberine metabolites, pharmacology.


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