European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ARTICLE ON TARGETED DRUG DELIVERY SYSTEM: DRUG TARGETING TO BONE MARROW

*Shireen Kahkashan Fatima and Dr. S. Shahid Mohammed

ABSTRACT

Targeted drug delivery (TDDS) an advanced method of delivering drugs to the patients such that increases the concentration of delivered drug to the targeted body parts only (organs/tissues/ cells) which in turn improves efficacy of treatment by reducing side effects.. Basically, targeted drug delivery assist the drug molecule to reach desired site i.e., bone marrow. Bone marrow is the organ which is responsible for production of blood cells in humans beings. BM also the 4th largest organ of the body by weight, consisting of bone, muscle, and fat. It is the seat of production of haematopoietic cells. It is estimated that, in humans, bone marrow accounts for approximately 4–5 % of the total body weight. The stem cells lines in the bone marrow produce new blood cells and stromal cells. It has been estimated that as many blood cells are eliminated from the blood circulation per day in adult human. Development of effective targeted bone marrow drug delivery systems is an important goal for development of diagnostic, protective, and/or therapeutic agents for hematopoietic disorders and infectious diseases.

Keywords: Blood cell production,stromal cell, blood cells, haematopoietic cell, bone marrow disease, hematopoietic disorders.