NANOMEDICINE AS A THERAPEUTIC WINDOW FOR THE TREATMENT OF BRAIN CANCER: RECENT DEVELOPMENTS AND FUTURE PROSPECTS
Ashu Chaudhary*, Pinki and Ashima Sharma
ABSTRACT
Malignant brain cancer treatment is limited by a number of barriers, including the blood-brain barrier, transport
within the brain interstitium, difficulties in delivering therapeutics specifically to tumor cells, the highly invasive
quality of gliomas and drug resistance. As a result, the prognosis for patients with high-grade gliomas is poor and
has improved little in recent years. Nanomedicine is a way in order to address these needs. The way through which
cancer development and targeting therapy can be understood is detection of somatic mutations in tumors. The
screening for BRAF V600E mutation is employed in clinical practice in Libya for its prognostic and potentially
predictive role in patients with metastatic colorectal carcinoma (mCRC). This review elaborate the obstacles that
come in route of treatment, also it tell us about different ways nanomedicine have been used to overcome them
with a focus on liposomal and polymeric nanoparticles.
Keywords: Brain tumor, Doxorubicin, Glioblastoma, Nanomedicine, Nanoparticle, Paclitaxel.
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