European Journal of Biomedical and Pharmaceutical Sciences

NANOMEDICINE AS A THERAPEUTIC WINDOW FOR THE TREATMENT OF BRAIN CANCER: RECENT DEVELOPMENTS AND FUTURE PROSPECTS

Ashu Chaudhary*, Pinki and Ashima Sharma

ABSTRACT

Malignant brain cancer treatment is limited by a number of barriers, including the blood-brain barrier, transport within the brain interstitium, difficulties in delivering therapeutics specifically to tumor cells, the highly invasive quality of gliomas and drug resistance. As a result, the prognosis for patients with high-grade gliomas is poor and has improved little in recent years. Nanomedicine is a way in order to address these needs. The way through which cancer development and targeting therapy can be understood is detection of somatic mutations in tumors. The screening for BRAF V600E mutation is employed in clinical practice in Libya for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). This review elaborate the obstacles that come in route of treatment, also it tell us about different ways nanomedicine have been used to overcome them with a focus on liposomal and polymeric nanoparticles.

Keywords: Brain tumor, Doxorubicin, Glioblastoma, Nanomedicine, Nanoparticle, Paclitaxel.