Abstract
CHARACTERIZATION OF ANTICANCER COMPOUND ISOLATED FROM PHYTOLACCA OCTANDRA AN IN VITRO AND IN SILICO ANALYSIS

D. Vithya Eswari* and S. F. Maleeka Begum

ABSTRACT

This study revealed an antioxidant and anticancer effect of the petroleum ether extract of P. octandra leaves. Qualitative analysis of plant showed the presence of alkaloid, flavonoid, tannin, saponin, steroid, phenol, glycoside and terpenoid. Column purified and TLC fractionated compound with Rf 0.86 showed potent antioxidant property and significantly differ among tests by doses depend manner. However, a minimum of 57 and maximum of 317 μg/mL of EC50 was recorded against FTC assay and Superoxide dismutase respectively. a cytotoxic analysis was thus carried out with breast cancer cell lines, which evidently showed remarkable anti-proliferative activities with IC50 value 148.17 μg. The active compound H1 reveals the presence of aromatic protons of bromine containing phenyl ring and imidazole phenyl ring and C13 shows presence of carbonyl group as a functional group. NMR studies of predicted compound and GCMS database reveals that the active compound was -(3-bromobenzoyl)-4-(4-chlorophenyl) piperidino [3,4- b]benzopyrrole. The present study suggested that Phytolacca octandra plant extract possess strong antioxidant and anticancer property.

Keywords: Alkaloids, Antioxidant, Breast cancer, anti proliferative, cytotoxic.


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