Abstract
FORMULATION AND CHARACTERIZATION OF MATRIX TYPE TRANSDERMAL PATCH USING AN ANALGESIC DRUG

Mohit Saini*, Sneha Singh, Nita Mondal and Amit Kumar

ABSTRACT

Transdermal drug delivery guide direct admittance to the systemic circulation through the skin which bypasses drugs from the hepatic first pass metabolism leading to increase bioavailability. Tramadol HCl has been selected as model analgesic drug. The Tramadol hydrochloride transdermal patches were prepared by solvent casting technique. Formulation of transdermal patches was selected by using different composition of polymers. Physicochemical properties such as thickness, weight uniformity, folding endurance, moisture content, percentage moisture uptake and content uniformity were determined on developed patches. In the present work an attempt was made to formulate the matrix type transdermal patch using Tramadol hydrochloride drug because it has low bioavailability.

Keywords: TDDS, Matrix type transdermal patch, Tramadol HCl & FT-IR.


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