European Journal of Biomedical and Pharmaceutical Sciences

THE STUDY OF RISK FACTORS AND ANTIBIOTIC RESISTANCE PROFILE OF SURGICAL SITE INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUS WITH SPECIAL REFERENCE TO METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

Dr. Swati Satish Kale*

ABSTRACT

Background: Surgical site infection (SSI) is one of the most common and serious complications following surgery. The incidence of the infected surgical wounds may be influenced by factors such as pre-operative care, the theatre environment, post-operative care and the type of surgery. S.aureus is the commonest cause of SSI and other nosocomial infections. The incidence of Methicillin Resistant S.aureus (MRSA) in various studies from India ranges from 30-70%. Material and methods: Staphylococcus aureus isolates obtained from various pus and wound swabs of surgical site infection patients received in Microbiology Diagnostic Laboratory at Government Medical College, Nagpur for the microbiological investigations were selected for the study. All samples were inoculated on Sheep blood agar and MacConkey’s medium and their antibiotic susceptibility was performed. Also the risk factors for SSI were determined accordingly. Results: A total of 158 pus samples were included in the study. Out of these, 48 Staphylococcus aureus clinical isolates were isolated from specimens of patients with SSI (30%).Out of these isolates, 28(58.33%) were MRSA and rest of them were MSSA(Methicillin Sensitive S.aureus). Conclusion: Due to the increased morbidity and mortality which are associated with S.aureus, an early detection and intervention is a prerequisite in surgical patients. Infection control guidelines for SSIs play a key role in reducing such infections.

Keywords: Surgical site infection (SSI), Staphylococcus aureus, Methicillin Resistant S.aureus (MRSA).