Abstract
PREPARATION AND EVALUATIONS OF DIATRIZOATE SODIUM LIQUID ORAL FORMULATION

Vishal D. Dakhale*, Dinesh P. Kawade, Srushti L. Wairagade

ABSTRACT

X-ray diagnostic agents (contrast media) are widely used as adjuncts to diagnostic visualization techniques as they help to illustrate the differences between tissues by introducing them to the area of interest to increase its density and absorption of X-rays. Diatrizoic acid is radio opaque ionic contrast media utilized orally and parentrally for symptomatic purpose. The goal of this investigation is to develop a liquid oral contrast media and evaluate the physicochemical parameter were compared with the changes in accelerated stability testing for the documentation of these plan nearby with FTIR information. Quality of final solution was evaluated with the parameters: pH, iodine iodide test and drug content. Three batches were formulated of the solution. All the batches were evaluated for physicochemical parameters, pH and drug content. The formulated batches under gone stability studies, no turbidity were observed for 60 days studies. All the batches assure the reproducibility and each parameter were complying with specifications.

Keywords: Diatrizoate sodium, oral liquid formulation, contrast media.


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