Abstract
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF BARK OF MANGIFERA INDICA AGAINST INH AND RIF INDUCED HEPATOTOXICITY IN RATS

A. Avinash*, B. Pravallika*, CH. Swathi*, K. Bhanu Prakash*, P. Swathi* and T. Bhanu Sri*

ABSTRACT

The present study was undertaken to evaluate the hepatoprotective activity of methanol extract of bark of Mangifera indica. It was evaluated in normal and Isoniazid (INH), Rifampicin (RIF) induced hepatotoxicity in rats. Liv.52 was used as a standard drug at a dose of 500mg/kg body weight given in oral route. Albino wistar rats with Isoniazid and Rifampicin induced hepatotoxicity were divided into 4 groups of 6 each. Hepatoprotective effect as two different doses 200 and 400 mg/kg body weight of methanolic extract of Mangifera indica would be investigated for 28 days to evaluate dose dependent activity. Effect of methanolic extract of Mangifera indica on Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetic transaminase Alkaline phosphatase, total cholesterol, total bilirubin were estimated for 0th, 7th, 14th, 21st, 28th day and antioxidant parameters were checked on 28th day of the scarification.

Keywords: Mangifera indica, Albino –Wistar rats, Isoniazid, Rifampicin, Hepatoprotective activity.


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