PROTECTIVE EFFECT OF PETROSELINUM CRISPUM OR ERUCA SATIVA EXTRACTS ON TESTES AGAINST DIOXIN INTOXICATION IN RATS
Gamal Mohamed Edrees, Hussam Ahmed El-Gayar*, El-Sayed Mohamed El Habibi, Eman Taha Salem
ABSTRACT
This study was conducted to investigate the effect of ethanolic extract of either Petroselinum crispum (PC) or
Eruca sativa (ES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) – induced toxicity on reproductive system of
male Albino rats. Forty two male rats were allocated to one of seven groups of six rats each: Control (NC), Corn
oil (CO), PC, ES, TCDD, PC+ TCDD and ES+ TCDD. All treatments continued for 5 weeks. Body, testicular and
epididymal weights were recorded, epididymal sperms were counted, free testosterone (FT),
dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH), luteinizing hormone (LH) levels, testicular
3β- hydroxysteroid dehydrogenase (3β-HSD) activity and apoptosis as assessed by flow cytometry were
estimated. The results showed that TCDD exposure resulted in a significant decrease in body weight, testicular
and epididymal weights, sperm count, FT, DHEA and 3β-HSD activity associated with significant increase in FSH
and LH as well as apoptosis in testes. However, when ethanolic extracts of either PC or ES were administered in
concomitant with TCDD, the estimated parameters tend to be nearly normalized. In general it could be concluded
that ethanolic extract of Eruca sativa has greater protective effect than alcoholic extract of Petroselinum crispum
in TCDD induced reproductive toxicity.
Keywords: TCDD, Testis, Eepidydimis, Eruca sativa, Petroselinum crispum, Apoptosis.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
