European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF LIPID PROFILE OF HUMAN IMMUNO DEFICIENCY VIRUS (HIV) AND TUBERCULOSIS (TB) POSITIVE PREGNANT WOMEN

*Omolumen L. E., Obodo B. N., Iyevhobu K. O., Okereke N. P., Idara I. U., Ebaluegbeifoh L. O., Ediale E. S. and Imodoye S. O.

ABSTRACT

Pregnancy is the time during which one or more offspring develops and is characterized by significant changes in metabolism, fluid balance, organ function and blood circulation. This study was set to evaluate the Lipid Profile of Human Immuno Deficiency Virus and Tuberculosis positive pregnant Women. A total of four hundred (400) subjects were recruited for this study which comprised of 150 HIV positive pregnant women, 150 TB positive pregnant women and 100 apparently healthy women which served as the control. Fasting Blood samples (4mls) were collected using standard aseptic technique into plain tubes for lipid profile estimation. The results revealed that the mean cholesterol values of HIV (197.45±38.56 mg/dl) and TB (185.65±18.88 mg/dl) positive pregnant women were not statistically significant (p>0.05) as compared to the controls (193.90±53.68 mg/dl). The mean values of Triglyceride (mg/dl) of the HIV positive pregnant women (181.53±26.31 mg/dl) was significantly higher (p<0.05) when compared with the control (148.32±49.98 mg/dl) and the TB positive pregnant women (128.55±22.64 mg/dl). High Density Lipoprotein was significantly higher (p<0.05) for HIV (47.75±7.53 mg/dl), but it was significantly lower for TB (37.95±3.60 mg/dl) when compared with the control (41.53±6.42 mg/dl). The mean values for low Density Lipoprotein for HIV (129.85±26.27 mg/dl) and TB (127.10±18.16 mg/dl) positive pregnant subjects was not statistically significant (p>0.782) when compared with the control (124.30±47.59mg/dl). There was no statistical significance (p<0.05) in the BMI (kg/m2) values of the HIV (25.35±2.21 kg/m2) and TB (24.30±2.36 kg/m2) positive pregnant women when compared with the control group, (25.35±2.21 kg/m2). However, this study revealed significant alterations in the lipid profile of HIV and TB positive pregnant women and hence could serve as a pointer in diagnosing and monitoring the progress of such patients.

Keywords: Pregnancy, Lipids, Infections, Transmission.