Abstract
NEUTROPHIL TO LYMPHOCYTE RATIO AS A PROGNOSTIC MARKER IN GALLBLADDER CARCINOMA: META-ANALYSIS

Arun Bhattarai, Lan liu, Prateek Rajkarnikar, Qiu Zhao*

ABSTRACT

The neutrophil to lymphocyte ratio (NLR) as prognostic factor of tumors are reported by many studies. By this meta-analysis, we have evaluated NLR prognostic role in gallbladder carcinoma (GBC). Pubmed and Embase were searched for relevant studies. Study data and characteristics were extracted. Prognostic role of NLR was analyzed using hazard ratio (HR) and 95% confidence interval (95%CI). Total of 4 observational studies with 892 patients were included for this meta-analysis. The pooled HR of 1.79 (95% CI: 1.51-2.13, P<0.01) showed patients having elevated NLR to have shorter overall survival (OS) after treatment. This meta-analysis suggests patient’s survival with gall bladder cancer can be predicted using elevated NLR.

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