EVALUATION OF MICROALBUMINURIA, RENAL FUNCTION AND LIPID IN ESSENTIAL HYPERTENSION
Rihab Akasha Mohamed Ali*, Amar Mohamed Ismail, Omer Fadul Edris
ABSTRACT
Background: Microalbuminuria is defined as urinary albumin excretion ranging from 30 – 300 mg/day,
microalbuminuria is a predictor for developing renal disease in diabetes, hypertension and recently for
cardiovascular disease. So it is important for early detection of renal damage in hypertension patients. Aim: This
study aim to measure microalbumin/creatinine ratio (MCR) in essential hypertensive adults and controls, also to
correlate the microalbumin/creatinine ratio with the duration of hypertension and to assess the renal function test
in patients with hypertension. Materials and Methods: Patients with essential hypertensive cases male and female
(n = 250) and normal subjects as controls (n = 250) were enrolled. The specimens include urine and serum;
Fasting urine sample for microalbumin–creatinine index, and 5 ml of venous blood was collected after 8 hours of
fasting and divided into fluoride oxalate container for glucose and an plain container (without anticoagulant) for
analysis of the other parameters. Concentration of microalbumin was measured by turbidimetry spectorphotometry
method, manufactured by BioSystem. Creatinine in serum and urine measured by using kinetic Jaffe method.
Descriptive statistics and correlation were used for the analysis using SPSS 20 software and Microsoft Office
Excel. Result: according to urinary excretion patients are classify to three groups; normal protein in urine group (n
= 185), microalbuminuria group (n = 39), and macroalbuminuria group (n = 26). A positive correlation was found
between duration of hypertension and MCR among patients P-value 0.000. A significant increase in blood urea
concentration over control value was seen. A significant increase in serum creatinine concentration over control
value was also seen. Conclusion: MCR is increase in hypertensive patients than control, and the positive
correlation between MCR and duration of hypertension, MCR well be a good marker for early detection of renal
damage.
Keywords: Microalbuminuria, turbidimetry spectrophotometry, creatinine.
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