European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF CALOTROPIS GIGANTEA TOPICAL GEL FOR ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY

Meena Kurup*, Dr. Pasupathi A. and Fasna Fazal

ABSTRACT

In pharmaceutical worlds, gel is the most convenient and patient friendly dosage form in the treatment of bacterial and fungal infection. The plants calotropis gigantea has been found to be used traditionally for its various therapeutic properties. In the present study a gel formulated by incorporating a herbal extract for its antimicrobial and antifungal activity. The gel where prepared using the concentrated Ethyl Acetate extract of dried leaf of Calotropis gigantea. The topical gel formulation where evaluated for its pH, appearance, homogenicity, viscosity spreadability and skin irritation studies. Antimicrobial studies performed by ditch plate method in in multiplication manner by using molar hinton Agar medium ignis a pathogenic bacterial strains is E coli. The antifungal activity of formulation were carried out by Gel diffusion method. The bacteria culture used were Candida albicans. Herbal gel where found 2 process compare table antimicrobial and antifungal effects so it can be used as a eco friendly dosage forms for the treatment of various microbial infections.

Keywords: Calotropis gigantea, antimicrobial and antifungal activity, topical gel.