Abstract
UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE MAGNESIUM AND DOMPERIDONE IN BULK AND PHARMACEUTICAL FORMULATION

Dinesh P. Kawade, Srushti L. Wairagade*, Vishal D. Dakhale

ABSTRACT

A novel, simple, sensitive and speedy spectrophotometric technique has been developed for simultaneous estimation of esomeprazole magnesium and domperidone in pharmaceutical form. This technique was primarily based wholly on ultraviolet light Spectrophotometric determination of two medicines, using simultaneous equation technique. The method involved solving simultaneous equation based on measurement of absorbance of 2 totally different wavelengths 301 nm and 287 nm, of esomeprazole and domperidone severally. Beer’s law was obeyed within the concentration range of 2-20 μg/ml and 2-20 μg/ml for esomeprazole and domperidone severally. The technique showed good reproducibility and recovery with % RSD. The method was found to express, accurate, and specific. The proposed technique was with success applied to estimation of esomeprazole and domperidone in combined dosage form. The technique was valid in the line with ICH guidelines.

Keywords: Esomeprazole, Domperidone, Simultaneous equation method, ICH guideline.


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