European Journal of Biomedical and Pharmaceutical Sciences

A STUDY TO EVALUATE HEPATO AND UTERO PROTECTIVE ROLE OF VITAMIN E IN ETHANOL FED OVARIECTOMIZED RATS

Maitrayee Banerjee, Ayon Roy, Priyanka Polley and Nirmal Pradhan*

ABSTRACT

Vitamin E has been attributed with a plethora of health- promoting actions. The purpose of this study was to reveal the hepato and utero protective role of vitamin E in ethanol treated bilateral ovariectomized rats. Experiments were carried out in – different group, as - A) Sham-operated control,B) Control+EtOH[ethanol], C)Bilateral Ovariectomized, D) Ovariectomized+EtOH,E) Ovariectomized+ Sesame oil and F) Ovariectomized + EtOH+ VitaminE. In this study of consicutive 30 days, significant hepatic damage was observed in bilateral ovariectomized rats treated with ethanol (0.5ml of 15% ethanol/100gm b.wt. /day) as reflected in their altered serum AST (SGOT), ALT (SGPT) and serum Alkaline phosphatase activity. Also, uterine regression was confirmed in this group of rats by significant lower uterine protein content and decreased activity of uterine AST, ALT and Alkaline phosphatase activity. Vitamin E supplementation (10mg/100gm b.wt.), apart from its unique influence in preventing hepatic damage, also could prevent ethanol induced uterine regression in ethanol fed bilateral ovariectomized rats.

Keywords: Vitamin E, Ethanol, Ovariectomized, Hepatic, Uterus.