FORMULATION AND EVALUATION OF POLYHERBAL TABLET FOR THE TREATMENT OF THYROID DISORDER
Tanmai N. Hatwar*, Pravin B. Suruse and Shilpa S. Borkar
ABSTRACT
Objective: The objective of the present study was to formulate polyherbal tablet for the treatment of thyroid disorders and to carry out evaluation of prepared polyherbal tablet. Methodology: Kanchanara, Guggul, Jatamansi, Trikatu, Brahmi, Amla, Amulthus, Chandrashoor, Methi and Giloy extracts were selected for the formulation of hypothyroid tablets to overcome the symptoms associated with thyroid disorders. The ethanolic extracts were subjected to qualitative chemical investigation to test for the presence of various phytochemical constituents in the extract and formulate hypothyroid tablet by wet granulation technique. Then film coating of tablets were carried out by Aquadry brown for taste masking and physical protection of tablets. Granules, uncoated tablet and coated tablets were evaluated for tests i.e. flow property, friability, dimension, hardness, disintegration time and drug content by HPTLC method. Microbial testing and stability study were performed to check the quality of product. Tablets were evaluated for determining its effects in the regulation of hypothyroidism using Albino wistar rat model. Serum triiodothyronine, thyroxine and thyroid stimulating hormone concentrations were tested as the end parameters of thyroid function in the study. Results: The tablets were evaluated for various parameters and the product were found to be within standard ranges and stable at stability and microbial testing and improves hypothyroidism activity in Albino rats. Conclusion: The hypothyroid tablet can find its application as thyroid supplement which can be given easily and safely to patients suffering from thyroid disorders.
Keywords: Thyroid disorder, hypothyroidism, chemical investigation, triiodothyronine, thyroxine, albino wistar.
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