Abstract
METHOD DEVELOPMENT AND VALIDATION OF METAXALONE BY UV SPECTROSCOPY

Dr. Juluri Krishna Dutta Tejaswi*

ABSTRACT

The proposed analytical method was simple, reliable, rapid, sensitive, reproducible and accurate for the estimation of Metaxalone. Metaxalone is a newer skeletal muscle relaxant and used along with rest and physical therapy to decrease muscle pain and spasms associated with strains, sprains or other muscle injuries. ELICO-SL244- Double Beam - UV – Visible spectrophotometer with pair of 10 mm matched quartz cells was used. Drug was dissolved in Methanol and was made further dilutions with Methanol to produce 20 μg/ml. It was scanned in the range of 200-400 nm and it shows constant λmax at 279.5 nm. Stability of the absorbance at their λmax was also checked for up to 4 hours. The optical characteristics such as Beer’s law limit (40-200μg/ml), Sandell’s Sensivity (0.181228971), correlation coefficient (0.9998), slope (0.00641) and intercept (0.00015) were calculated. The limit of detection was found to be 0.301404286 μg/ml and the limit of quantification was found to be 0.913346321 μg/ml. The drug samples were analyzed by UV spectroscopy using methanol as solvent and the content of drug present in the formulation was found to be 399.17 mg (99.79%). The above method does not suffer from any interference due to common excipients.

Keywords: Metaxalone, UV spectroscopy, Methanol.


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