European Journal of Biomedical and Pharmaceutical Sciences

IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF TURMESAC® ON CHEMICALLY INDUCED INFLAMMATION IN EXPERIMENTAL MODELS

Firoz H. M., Nanjundaiah S. and Sadashiva C. T.*

ABSTRACT

The objective of the present study was to evaluate the anti-inflammatory activity of Turmesac® on chemically induced inflammation in experimental animals. Oral administration of Turmesac® in two different doses (250 and 500 mg/kg body weight) by using 5% croton oil induced ear edema and 1% histamine induced paw edema test. Diclofenac sodium (10mg/kg) was used as a standard drug. The anti-inflammatory activity was evaluated using croton oil induced ear edema model in mice and histamine-induced paw edema model in wistar albino rats. The anti-inflammatory activity was found to be dose dependent on croton oil induced ear edema model. The Turmesac® has shown significant (P < 0.05) inhibition of ear edema, 58.65% on 2hr and 57.25% on 4hr at the doses of 500 mg/kg, respectively. Similar patterns of paw edema inhibition was seen in histamine induced paw edema model at the doses of 250mg/kg and 500 mg/kg, respectively. In conclusion, the present study demonstrated potent anti-inflammatory activity of Turmesac® in both acute (croton induced ear edema and histamine induced paw edema) inflammation models.

Keywords: Turmesac®, anti-inflammatory activity, croton oil, histamine paw edema, Diclofenac sodium.