Abstract
EXPLORING DRY CO-GRINDING APPROACH AS A TOOL TO IMPROVE THE DISSOLUTION RATE OF POORLY SOLUBLE DRUG

Alaa Y. Bazeed*, Ahmed Nouh, Ebtessam A. Essa and Gamal M. El Maghraby

ABSTRACT

Nateglinide is a non-sulphonylurea which was approved for treatment of type II diabetes mellitus. It shows a pH dependent solubility that resulted in a variable and incomplete oral bioavailability, that may put the diabetic patient at risk. This work introduces dry co-grinding of the drug with inert carrier as a method for enhanced dissolution rate of nateglinide. Aerosil 200 was used as an inert excipient. Three formulations were prepared at different molar ratios (1:1, 1:2 and 1:3 drug to aerosil 200). Drug dissolution was monitored before and after processing. The developed formulations showed significant increase in drug dissolution compared to the unprocessed nateglinide. This study introduced the dry co-grinding process as a solvent free technique, which can be performed during the regular production process, as a promising tool to improve dissolution rate of poorly soluble drugs.

Keywords: Nateglinide, Aerosil 200, colloidal silicon dioxide, co-processing.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW JUNE ISSUE PUBLISHED

    JUNE 2020 Issue has been successfully launched on 1 June 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT