European Journal of Biomedical and Pharmaceutical Sciences

PROPOSAL FOR LIPID-BASED DRUG DELIVERY SYSTEM: DEFINITION, RECOMMENDATIONS, FORMULATION STRATEGIES, FEATURES AND FUTURE ASPECTS

Neha Sahu* and Khushboo Gupta

ABSTRACT

The principle objective of formulation of lipid-based drugs is to reinforce their bioavailability. the utilization of lipids in drug delivery is not any more a replacement trend now but remains the promising concept. Lipid-based drug delivery systems are one of the emerging strategies designed to deal with challenges just like the solubility and bioavailability of poorly water-soluble drugs. These formulations are synthesized to meet a huge range of product specifications largely determined by sign of disease, route of administration, cost consideration, product security, toxicity and effectiveness. These formulations also are a commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary, or parenteral delivery. Additionally, lipid-based formulations are shown to scale back the toxicity of varied drugs by changing the biodistribution of the drug faraway from sensitive organs. However, the amount of applications for lipid-based formulations has expanded because the nature and sort of active drugs under investigation became more varied. This paper mainly focuses on novel lipid-based formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories also as on their prominent applications in pharmaceutical drug delivery.

Keywords: Drug, Lipid based formulation, Bioavailability, Administration.