Abstract
PHARMACEUTICAL CO-CRYSTALLIZATION: AN AEON IN SOLUBILITY ENHANCEMENT

*Ankita A. Orpe, Pranali S. Band, Vijay P. Munde

ABSTRACT

Cocrystal concept of the supramolecular chemistry is gaining wide interest of researchers from pharmaceutical, chemical sciences, and regulatory agencies. Pharmaceutical cocrystal engineering has emerged as a new era in the field of medicine in developing a new moiety with improved solubility, dissolution, bioavailability, micrometric properties, and pharmacokinetic and pharmacodynamic properties of a drug. Different methods have been used for the synthesis of cocrystal such as grinding, slurry, antisolvent, hot melt extrusion, sonocrystallization, supercritical fluid, spray drying etc. The article highlights the co-crystallization, its methods and significance.

Keywords: Pharmaceutical Co-crystals, Co-crystallization, solubility, stability, bioavailability, Grinding, Slurry conversion.


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