European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON “NOVEL ANTI FUNGAL GEL FORMULATION”

Nayan Ashok Mule* and S. D. Pande

ABSTRACT

Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections. Skin is one of the most readily accessible organs on human body for topical administration and is main route of topical drug delivery system. Carbopol based gel formulations with Voriconazole were made. The formulation study was aimed to keep all other ingredients constant and only change in Carbopol 940 concentrations. Gel formulations were characterized for Physical Evaluation, Rheological Studies, Sensitivity Test, Skin Irritation Test, In-vitro drug diffusion through animal membrane for the optimized formulation and in-vitro antifungal activity. The results were found satisfactory for all the parameters studied.

Keywords: Voriconazole, Carbopol 940, gel, gel forming agents, topical delivery, antifungal activity, skin irritation.