European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF PIROXICAM EMULGEL FOR TOPICAL DRUG DELIVERY SYSTEM

Imran Husain Ahmad Husain* and V. P. Wankhade

ABSTRACT

The present work is concerned with the formulation and evaluation of Piroxicam emulgel employing carbopol 934 and xanthan gum as polymers. The emulgel is prepared by combining the gel and emulsion. The gel in formulations were prepared by dispersing Carbopol 934 and xanthan gum separately in purified water with constant stirring at a moderate speed and then the pH was adjusted to 6 to 6.5 using Tri-ethanol amine (TEA). The oil phase in the emulsion consists of liquid paraffin and span-80. The aqueous phase in the emulsion was prepared using Tween-80 and distilled water. The prepared emulgel formulations were subjected to evaluation studies like Physical appearance, ph determination, estimation of drug content and invitro drug release. The appearance of prepared emulgel was white. The emulgel were prepared using various concentration of Carbopol-934 and penetration enhancers (Clove oil and Eucalyptus oil) from batch F1 to F8. The results shown that all prepared formulations having good homogeneity, uniform consistency with smooth texture, good spreadability, extrudability, swelling index, and constant drug content.

Keywords: Piroxicam, Emulgel, Carbopol 934, Xanthan gum.