European Journal of Biomedical and Pharmaceutical Sciences

ADMINISTRATION OF THE DRUG TO EFFECTIVELY KILL THE CANCER CELLS ONLY, WITHOUT DAMAGING THE HEALTHY CELLS, IN EFFECTIVE COST USING NANOBOTS

*Nirnimesh De, Souhardya Roy and Subham Ghosal

ABSTRACT

Drugs that target microtubules are thought to inhibit cell division and cell migration by suppressing dynamic instability, a ―Search & Capture‖ behavior that allows microtubules to probe their environment. Here, we report that subtoxic drug concentrations are sufficient to inhibit plus-end microtubule dynamic instability and cell migration without affecting cell division or microtubule assembly. The higher drug concentrations needed to inhibit cell division act through a novel mechanism that generates microtubule fragments by stimulating microtubule minus-end detachment from their organizing centers. The frequency of microtubule detachment in untreated cells increases at prophase suggesting that it is a regulated cellular process important for spindle assembly and function. We observed that drugs produce differential dose-dependent effects at microtubule plus and minus-ends to inhibit different microtubule-mediated functions. This is the basic mechanism of an anti-cancer drug. We are using different techniques to identify the mutated genes as well as 3D protein structure analysis for Mutation Data scoring and Hotspot founding for cancer analysis. We have introduced several markers for this identification process. By this suitable identification, the novelty of the approach comes with the use of the Nanorobots (Nanobots or Nanoids) i.e. typically devices ranging in size from 0.1-10 μm and constructed of Nanoscale or molecular components. As non artificial non-biological Nanorobots have so far been created, they remain a hypothetical concept at this time. Nanobots and its uses Nanobots are robots that carry out a very Specific function and are 50-100 nm Wide. They can be used very effectively for drug delivery. Normally, drugs work through the entire body before they can reach the disease-affected area. Using Nanotechnology, the drug can be Targeted to a precise location which would make the drug much more Effective and reduce the chances of Possible side effects. A great advantage of using Nanobots for drug delivery is that the amount and time of drug release can be easily controlled by controlling the electrical pulse. Furthermore, the walls dissolve easily and are therefore harmless to the body. Description of all the process as well as the mechanisms are explained in this paper.

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