THE PHARMACOKINETIC STUDY OF ASPIRIN, PARACETAMOL AND NAPROXEN WITH MAGNESIUM SULFATE
Prof. Nikhil S. Bhujbal*, Chetan P. Saswade, Gaurav M. Prajapati, Dr. Sandip S. Kshirsagar and
Dr. Rajesh J. Oswal
ABSTRACT
The present study was designed to evaluate the bioavailability of single drug as well as drug with Mg(II) complexes in the systemic circulation of rats. 132 healthy rats were selected for this study. The rats were fasted for 12 hours (overnight) prior to drug administration and kept fasting up to blood collection after administration of the drugs. The rats were divided in to three groups for each drug of study: control (rats without giving any drugs for each analysis) and group 1 for reference (single drug) and group 2 for test drug i.e. drug-Mg complexes. In this study both the test (drug-Mg complex) drug and corresponding reference drug were administered at the dose of aspirin at 10 mg/kg body weight, paracetamol at 16 mg/kg body weight and naproxen at 16 mg/kg body weight in the solution form through oral route. From the pharmacokinetic study, it was found that concomitant administration of magnesium with aspirin slightly increased elimination rate and lowered the bioavailability than the reference aspirin. When magnesium was concomitantly administered with paracetamol, it markedly increased elimination rate and decreased the bioavailability than that of the reference paracetamol. When magnesium was concomitantly administered with naproxen, it decreased elimination rate and remained in the systemic circulation for longer time.
Keywords: Bioavailability, Paracetamol, Aspirin, Magnesium Sulfate, NSAID.
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