Abstract
A CLINICAL CASE REPORT ON PREDICTABLE DRUG-INDUCED LIVER INJURY

Sri Latha L., Mounika D.*, Dr. Anjana Male, Dr. CH. Manoj Kumar and Jyothi Vamsi Krishna G.

ABSTRACT

Drug-induced hepatitis is one of the major drug-related problems which a general practitioner encounters in his clinical practice. Predictable Drug-Induced Liver Injury is generally characterized by certain dose-related injury in experimental animal models, has a higher attack rate, and tends to occur rapidly. Injurious free radicals cause hepatocyte necrosis in zones farthest from the hepatic arterioles, where metabolism is greatest and antioxidant detoxifying capacity is the least. Unpredictable or idiosyncratic reactions comprise most types of DILI. These hypersensitivity or metabolic reactions occur largely independent of dose and relatively rarely for each drug, and may result in hepatocellular injury and/or cholestasis. This is a case report focusing on a 46 years female patient who experienced hepatotoxicity after administration of antitubercular drugs, like Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol are the first-line agents in the treatment of Tuberculosis. The patient was receiving anti-tubercular drugs for 6 months and developed hepatitis, which is a severe adverse drug reaction of Antitubercular medications. Naranjo's causality assessment algorithm was used to assess the adverse effect and it indicated anti-tubercular drugs as a probable cause of hepatitis. Hepatotoxicity is typically distinctive or dose-dependent measurements of AST, bilirubin, and alkaline phosphates are adjunctive for monitoring severe hepatocellular injury. We have reported this clinical case because of its scarcity in clinical practice.

Keywords: Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW JUNE ISSUE PUBLISHED

    JUNE 2020 Issue has been successfully launched on 1 June 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT