MINIMIZATION OF INITIAL BURST IN ALGINATE HYDROGEL BEADS BY IONOTROPIC GELATION METHOD
Sanni Gangwar*, Uday Prakash and Dr. Atul Gangwar
ABSTRACT
The work investigates the minimization of initial burst in alginate hydrogel beads by ionotropic gelation method. The design of effective and safe drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deliver drugs over a long period of time or for a well-controlled release profile, to minimizing the loss of drug, to reduce the side effect. The beads were prepared by using sodium alginate coated with chitosan, containing Metformin hydrochloride by ionotropic gelation using central composite design. The influence of various formulation factors such as In-vitro drug release, drug entrapment efficiency, swelling study, bead size and micromeritic properties, was investigated. These were also characterized by Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) analysis. Metformin hydrochloride containing hydrogel beads were in the size range of 1.84±0.02 to 2.00±0.15 mm. Metformin hydrochloride loading amount, concentration of chitosan, polymer concentration and cross-linking agent seemed to affect the values of particle size. It was found that the particle size decreased significantly by increasing sodium alginate concentration. The drug entrapment efficiency was found in the range of 86.14±1.85 to 93±1% and the drug release were found at 8 h in the range 70±0.49% to 90.84±0.94%. The release pattern observed was a biphasic, characterized by an initial burst effect followed by slow release. No significant change was found in the drug content of drug-loaded beads, stored at room temperature and 40°C after 60 days of study.
Keywords: Hydrogel beads, Metformin hydrochloride, Sodium alginate, chitosan, Ionotropic gelation technique, Optimization.
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